Research Article: Novel finding on anticoagulant activity of Canna warszewiczii extracts
Thi Van Anh Nguyen, Huong Duong Thi Ly, Thi Thom Vu, Thi Thu Nguyen, Hong Luyen Le
Abstract
Canna warszewiczii is a traditional medicine used to treat cardiovascular diseases like coronary artery disease, myocardial ischemia. However, the pharmacological effects of this plant have not been studied yet. This study aimed to investigate for the first time the anti-coagulant activity of Canna warszewiczii extracts. Rhizomes and the upper parts (leaves and shoots) of the plant were extracted by 90% ethanol, then fractioned by nhexane, dichloromethane, ethyl acetate and distilled water. Human plasma collected from healthy volunteers was treated with the ethyl acetate and aqueous extracts at different concentrations (2, 4, 8, 16 mg/mL), then the prothrombin time (PT) and activated partial thromboplastin time (APTT) were measured. The results showed a novel finding that the crude ethyl acetate extracts of both rhizomes and upper parts prolonged significantly both PT and APTT at the concentration of 8 mg/mL and 16 mg/mL (P < 0.05). These preliminary results suggest that Canna warszewiczii extracts can be a potential source of anticoagulant compounds and may be useful in the treatment and prevention of thrombotic disorders.
Keywords: medicinal plants, antiprotozoal, pharmacology
Thi Van Anh Nguyen, Huong Duong Thi Ly, Thi Thom Vu, Thi Thu Nguyen, Hong Luyen Le
Abstract
Canna warszewiczii is a traditional medicine used to treat cardiovascular diseases like coronary artery disease, myocardial ischemia. However, the pharmacological effects of this plant have not been studied yet. This study aimed to investigate for the first time the anti-coagulant activity of Canna warszewiczii extracts. Rhizomes and the upper parts (leaves and shoots) of the plant were extracted by 90% ethanol, then fractioned by nhexane, dichloromethane, ethyl acetate and distilled water. Human plasma collected from healthy volunteers was treated with the ethyl acetate and aqueous extracts at different concentrations (2, 4, 8, 16 mg/mL), then the prothrombin time (PT) and activated partial thromboplastin time (APTT) were measured. The results showed a novel finding that the crude ethyl acetate extracts of both rhizomes and upper parts prolonged significantly both PT and APTT at the concentration of 8 mg/mL and 16 mg/mL (P < 0.05). These preliminary results suggest that Canna warszewiczii extracts can be a potential source of anticoagulant compounds and may be useful in the treatment and prevention of thrombotic disorders.
Keywords: medicinal plants, antiprotozoal, pharmacology
