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Skin Care Active Ingredients from Senna alata (L.) Roxb Extracts
Saidatul Husni Saidi, Nor Azah Mohamad Ali, Nurhazwani Mohd Hirmizi, Norulaiman Yusoff, Zunoliza Abdullah, Shalini Markandan, Mary Khoo, Mazura Pisar, Mailina Jamil, Tan Ai Lee, Nuziah Hashim, and Safiatunnuur Mohamed Salleh Caadir

Abstract
Senna alata (L.) Roxb. (S. alata ) locally known as “gelenggang daun kecil” in Malay language has been used traditionally to treat skin ailments such as rashes and ringworm. In this study, the leaf extracts of S. alata were prepared by (i) undergoing proper species authentication, (ii) quality control of the raw materials, (iii) extraction, (iii) chemical profiling, and (iv) bioactivity evaluation. Antioxidant and anti-inflammatory properties of the extracts were determined by the DPPH radical scavenging assay, total phenolic content assay, tyrosinase inhibitory assay, and lipoxygenase assay. The safety of the extract was determined by conducting cytotoxic test on normal kidney and hepatic cell lines. Based on the bioactivity properties, an active ingredient for skin care formulations was developed and incorporated in facial serum formulation as a prototype product. The prototype product was tested for stability, pH value, physical, and skin irritation. S. alata has the potential to be developed as skin care active ingredient however further study is required in addressing the mechanism of action of the extract in skin care protection.

Keywords: Senna alata, Medicinal plant, Skin care active ingredient