In Vitro Anthelmintic Efficacy of Spathodea campanulata P. Beauv. (Bignoniaceae) Against Pheretima posthuma
Anita Wag, Dr. Santosh Butle, Priyanka Telang
Abstract
To investigate the anthelmintic activity of leaves of Spathodea campanulata P. Beauv. (Bignoniaceae) against Pheretima posthuma (Indian earthworms).The methanolic extract of the leaves of Spathodea campanulata P. Beauv. (Bignoniaceae) was investigated for anthelmintic efficacy against Indian adult earthworms (Pheretima posthuma). Earthworms were grouped and treated with extracts at 5, 15 and 20 mg/ml concentration, albendazole as a standard and normal saline as control. The paralysis time and death time of earthworms is considered as a indicator for anthelmintic activity. Methanolic extract of leaves of Spathodea campanulata showed dose dependent anthelmintic activity but significant activity was observed at 20 mg/ml concentration. At 20 mg/ml concentration extract, showed better activity with paralysis time (4.23 min) and death time (10.32 min) when compared to standard drug albendazole.The study reveal that the methanolic extract of Spathodea campanulata P. Beauv. leaves has significant anthelmintic activity against Indian adult earthworms.
Keywords: Spathodea campanulata; Anthelmintic activity; Albendazole; Methanolic extracts
Anita Wag, Dr. Santosh Butle, Priyanka Telang
Abstract
To investigate the anthelmintic activity of leaves of Spathodea campanulata P. Beauv. (Bignoniaceae) against Pheretima posthuma (Indian earthworms).The methanolic extract of the leaves of Spathodea campanulata P. Beauv. (Bignoniaceae) was investigated for anthelmintic efficacy against Indian adult earthworms (Pheretima posthuma). Earthworms were grouped and treated with extracts at 5, 15 and 20 mg/ml concentration, albendazole as a standard and normal saline as control. The paralysis time and death time of earthworms is considered as a indicator for anthelmintic activity. Methanolic extract of leaves of Spathodea campanulata showed dose dependent anthelmintic activity but significant activity was observed at 20 mg/ml concentration. At 20 mg/ml concentration extract, showed better activity with paralysis time (4.23 min) and death time (10.32 min) when compared to standard drug albendazole.The study reveal that the methanolic extract of Spathodea campanulata P. Beauv. leaves has significant anthelmintic activity against Indian adult earthworms.
Keywords: Spathodea campanulata; Anthelmintic activity; Albendazole; Methanolic extracts
