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Nano-Berberine as a Fungicide and Bactericide: An In Vitro Evaluation on Vaginal Isolations
Nguyen Nhi Ha, Ha Thi Thanh Huong, Le Quang Huan, Pham Thi Van, Phan Van Hau, Dang Thi Ngan, Le Ngoc Than, Vu Thi Thom

Abstract
Background: Herbal-based products contribute a part in feminine hygiene ones. Several plants extracts have been components of different washing solutions. Berberine nanoparticles had a potential minimum inhibitory concentration against some microbes in comparing to standard antibiotics. Objective: Our studies aimed to evaluate the activities of nano berberine against some microbial strains isolated from vaginal samples. Materials and Methods: The antifungal and antibacterial activity of nano berberine extract 10%, 5% and 2.5% against Candida albicans, Enterococcus faecalis, Escherichia coli and Klebsiella pneumoniae was determined by agar dilution agar method. Results: Candida albicans and Enterococcus faecalis did not yield on nano berberine containing plates while Escherichia coli and Klebsiella pneummoniae grew well. Conclusion: Nano berberine solution might be used as a potential washing product supporting vulvovaginitis candidiasis control.

Keywords: Antibacterial, antifungal, nano-berberine, vaginitis