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Prolificacy of reproductive stimuli in Senna siamese methanol crude extract of female Rattus Norvegicus
MacDonald Idu, Odaro Timothy, Benjamin O. Gabriel

Abstract
Infertility is a persistence ineptitude to develop into pregnancy successively after 12 months of continuous, precarious sex between couples or recurrent sexual intercourse. This study investigates the fecundity potential in Senna siamea methanol extract in female Wistar rats. Standard method was inculcated using female Wistar rats weighing 190-210 g. five experimental groups (n=5) were randomly selected after acclimatization. Fertility study was assay for in-vivo antioxidant study, hormonal indexes, lipid profile and histopathological study of graded doses at 25, 50, 100 mg/kg Senna siamea methanol extract. The analysed antioxidant assay exhibit a broader scavenging effects against radicals’ oxidative stress in enzymatic in-vivo assay via a significant decrease (p> 0.05) in Malondialdehyde (MDA) concentration with a slight increase in superoxide dismutase (SOD), catalyse and glutathione peroxidase levels, which perhaps could be implicated as one of the mechanisms of action through which the extract elicit its efficacy. The extract stimulate the release of oestrogen, follicle stimulating hormone, luteinizing hormone and progesterone with a significant increase (p> 0.05) level across the test groups when compared with the untreated control. A slight increase in cholesterol, triglyceride, high density lipoprotein (HDL), low density lipoprotein (LDL) and very low density lipoprotein (VLDL) concentration in the treatment groups when compared with the control and Vitamin E. the histopathological study showed no damaging architectural variation on the testes of the test groups in comparative to the untreated control. In conclusion, the fertility effect of the extract validates the plant folkloric uses for therapeutic purposes.

Keywords: Reproductive, Prolificacy, Senna Siamese, Rattus norvegicus