Pharmaceutical development and standardization of a novel polyherbal topical application for complexion enhancement, based on the “Varnya Dashakaya”
De Silva C.S, Senarathne U. R. S. R. K.
Abstract:
Context: The global popularity of skin complexion enhancers has surged in the present era. Numerous such products are disreputable due to the inclusion of harsh chemicals that often result in skin damage. The Varnya Dashakaya mentioned in the Charaka Samhita is a herbal group specifically indicated for skin complexion enhancement. Objective: to develop a purely natural poly-herbal topical application containing selected ingredients from Varnya Dashakaya to enhance skin complexion and accomplish its pharmaceutical standardization. Methods: herbal ingredients were selected based on their availability, feasibility, and efficacy towards skin conditions. Virgin coconut oil and beeswax were used as the base, and no artificial ingredients were added. The product was developed following the Malahara Kalpana process mentioned in Rasa Tharangini. Three replicates were prepared to standardize the process and mean, and standard deviation values were applied to standardize the product. Analytical parameters including organoleptic parameters, homogeneity, spread-ability, pH values, moisture content, total ashes value, saponification value, qualitative phytochemical screening, development of TLC were conducted. Results: low moisture, total ash and saponification values were observed as well as stability of the product. Phytochemical screening detected alkaloids, tannins, flavonoids and terpenoids. Conclusion: our polyherbal topical application is a potential agent for the enhancement of skin complexion; however, further clinical studies are needed to accurately determine its safety and efficacy.
Keywords: ayurveda, pharmaceutical standardization, formulation, skin complexion, varnya dashakaya
De Silva C.S, Senarathne U. R. S. R. K.
Abstract:
Context: The global popularity of skin complexion enhancers has surged in the present era. Numerous such products are disreputable due to the inclusion of harsh chemicals that often result in skin damage. The Varnya Dashakaya mentioned in the Charaka Samhita is a herbal group specifically indicated for skin complexion enhancement. Objective: to develop a purely natural poly-herbal topical application containing selected ingredients from Varnya Dashakaya to enhance skin complexion and accomplish its pharmaceutical standardization. Methods: herbal ingredients were selected based on their availability, feasibility, and efficacy towards skin conditions. Virgin coconut oil and beeswax were used as the base, and no artificial ingredients were added. The product was developed following the Malahara Kalpana process mentioned in Rasa Tharangini. Three replicates were prepared to standardize the process and mean, and standard deviation values were applied to standardize the product. Analytical parameters including organoleptic parameters, homogeneity, spread-ability, pH values, moisture content, total ashes value, saponification value, qualitative phytochemical screening, development of TLC were conducted. Results: low moisture, total ash and saponification values were observed as well as stability of the product. Phytochemical screening detected alkaloids, tannins, flavonoids and terpenoids. Conclusion: our polyherbal topical application is a potential agent for the enhancement of skin complexion; however, further clinical studies are needed to accurately determine its safety and efficacy.
Keywords: ayurveda, pharmaceutical standardization, formulation, skin complexion, varnya dashakaya
